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In Vitro Drug Screening
Translational Development
Translational Development
- Cytotoxicity and proliferation assays: MTT/CellTiter Glo/BrDU/CFSE; 3 D cell culture; cell cycle analysis; microtubule and mitosis test
- Angiogenesis assays: endothelial cell proliferation, adhesion, migration, invasion, chemotaxis, tubule formation, aorta ring explant, VEGFR signaling
- Epigenetics assays: Acetyltransferase, DNA Methyltransferase, HDAC, Histone Demethylase, Histone Methyltransferase, Bromodomain, PARP screening and profiling
- Cell free assays: various kinase, phosphatase, and other enzymatic assays
- Reporter gene assays
- Analysis of post-translational modification of proteins
Translational Development
Translational Development
Translational Development
- Biomarker validation and measurement using SimpleWestern, various immunoassays and other
- Characterization of mechanism of action of novel drugs
- Target identification and validation of drug candidates and novel compounds
- Drug combination screening for synergistic studies (CalcuSyn analysis for synergy)
- Development of companion diagnostic methods
- Simultaneous multiplex analysis of gene and protein expression.
PROTAC Discovery
Translational Development
Live Cell Imaging
- Identify and characterize new, potent, and selective ligands that bind and reprogram E3 ligase substrate specificity with our ligand binding assay.
- Develop, characterize, and validate the warhead end of novel PROTACs.
- Enable sensitive quantitation of PROTAC-mediated degradation of targets for DC50 and Dmax values
- Evaluate the impact of target degraders on efficacy and safety-related translational biomarkers with our automatic western blot, IHC and other platforms.
- Characterize PROTAC selectivity across the proteome and provide a global readout on changes in protein expression using protein microarray such as RPPA.
- Provide on-shelf assays, such as CRBN, BET-VHL binding assay, VHL and CRBN ternary complex formation assay
Live Cell Imaging
Gene and Protein Microarray
Live Cell Imaging
- Cell adhesion, migration, chemotaxis and wound healing
Gene and Protein Microarray
Gene and Protein Microarray
Gene and Protein Microarray
- Genome-wide gene array, low density gene array, real-time RT-PCR
3-D In Vitro Models
Gene and Protein Microarray
Gene and Protein Microarray
- 3-D anti-psoriatic drug screening
- 3-D cancer cell viability assay
- 3-D spheroid cell invasion assay
- 3-D tumor micro-tissue assay
- 3-D anti-skin aging cosmetic ingredient screening
Animal Model for Cancers
Animal Model for Inflammation
Animal Model for Inflammation
- Mouse tumor models using patient cancer cells or cell lines (PDX or xenograft models)
- Angiogenesis models using mice and zebra-fish
- Microbiopsy sampling and real-time monitoring efficacy and toxicity of drugs
Animal Model for Inflammation
Animal Model for Inflammation
Animal Model for Inflammation
- Topical arachidonic acid-induced inflammation model (rodent)
- Adjuvant-induced rheumatoid arthritis model (rodent AIA)
- Collagen-induced arthritis models (CIA)
- Experimental Autoimmune Encephalomyelitis model (rodent EAE)
- OVA-induced asthma rodent model
- Pristane-Induced Systemic Lupus Erythematosus model (mouse SLE)
- MRL/lpr genetic Systemic Lupus Erythematosus model (mouse SLE)
- Inflammatory Bowel Disease models
- Delayed-Type Hypersensitivity model
- FITC Induced Dermatitis mouse model
- Imiquimod-induced Psoriasis model
- Bleomycin-induced Pulmonary Fibrosis mouse model
In vitro Toxicology/Safety Test
Animal Model for Inflammation
In vitro Toxicology/Safety Test
- Analysis of DNA damage (comet, DNA fiber assay), DNA oxidation; DNA methylation
- Ames test (bacterial reverse mutation, 2 or 5 strains
- Micronucleus test (MNT)
- Mitochondrial toxicity
- CFU assay for hematotoxicity assessment
- Colony-forming cell-fibroblast (CFU-F) assay for mesenchymal toxicity assessment
- Cell-specific cytotoxicity
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